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Writer Harry Block draws inspiration from people he knows, and from events that happened to him, sometimes causing these people to become alienated from him as a result.

Ella Peterson works in the basement office of Susanswerphone, a telephone answering service. She listens in on others' lives and adds some interest to her own humdrum existence by adopting different identities for her clients. They include an out-of-work Method actor, a dentist with musical yearnings, and in particular playwright Jeffrey Moss, who is suffering from writer's block and desperately needs a muse.

A theater director struggles with his work, and the women in his life, as he attempts to create a life-size replica of New York inside a warehouse as part of his new play.

A simple-minded gardener named Chance has spent all his life in the Washington D.C. house of an old man. When the man dies, Chance is put out on the street with no knowledge of the world except what he has learned from television.

On the brink of turning 30, a promising theater composer navigates love, friendship and the pressure to create something great before time runs out.

Dallas, a burdened but headstrong dancer, is determined to get into the best dance school in the country—her late mother’s alma mater. However, that dream is suddenly derailed when the cheeky yet secretly grieving football star, Drayton, crashes into her life with a unique story of his own. Will the two of them be able to grow into their dreams together, or will their dreams be sidelined?

A Los Angeles journalist befriends a homeless Juilliard-trained musician, while looking for a new article for the paper.

Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman and Orlean's book become strangely intertwined as each one's search for passion collides with the other's.

Aspiring actor Edward undergoes a radical medical procedure to drastically transform his appearance. But his new dream face quickly turns into a nightmare.

In 1962 New York City, love blossoms between a playboy journalist and a feminist advice author.